Skip First Level Navigation | Skip All Navigation

Home > Publications

Selected Publications

The manuscripts available on our site are provided for your personal use only and may not be re-transmitted or redistributed without written permissions from the paper's publisher. You may not upload any of this site's material to any public server, on-line service, or bulletin board without prior written permission from the publisher and authors. You may not make copies for any commercial purpose.  Reproduction of materials retrieved from this web site is subject to the U.S. Copyright Act of 1976, Title 17 U.S.C.

K.G. Schaefer, A.E. Pittman, F.N. Barrera, & G.M. King, Atomic force microscopy for quantitative understanding of peptide-induced lipid bilayer remodeling, Methods, in press (2020). DOI: 10.1016/j.ymeth.2020.10.014

K.G. Schaefer, B. Grau, N. Moore, I. Mingarro, G.M. King, & F. Barrera, Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax, Faraday Discussions, in press (2020). DOI: 10.1039/D0FD00070A

G.M. King, & I. Kosztin, Towards a Quantitative Understanding of Protein Lipid Bilayer Interactions at the Single Molecule Level: Opportunities and Challenges, J. Membrane Biol, in press (2020). DOI: 10.1007/s00232-020-00151-0

P.H. Nguyen, K.P. Sigdel, K.G. Schaefer, G.A.K. Mensah, G.M. King, & A.G. Roberts, The effects of anthracycline drugs on the conformational distribution of mouse P-glycoprotein explains their transport rate differences , Biochemical Pharmacology 174, 113813 (2020). DOI: 10.1016/j.bcp.2020.113813

T.R. Matin, M. Utjesanovic, K.P. Sigdel, V.F. Smith, I. Kosztin, & G.M. King, Characterizing the Locus of a Peripheral Membrane Protein-Lipid Bilayer Interaction Underlying Protein Export Activity in E. coli , Langmuir 36, 2143 (2020). DOI: 10.1021/acs.langmuir.9b03606

K. Chattrakun, D.P. Hoogerheide, C. Mao, L.L. Randall, & G.M. King, Protein Translocation Activity in Surface-Supported Lipid Bilayers , Langmuir 35, 12246 (2019). DOI: 10.1021/acs.langmuir.9b01928 [Also see Correction]   

R.R. Sanganna Gari, K. Chattrakun, B.P. Marsh, C. Mao, N. Chada, L.L. Randall, & G.M. King Direct visualization of the E. coli Sec translocase engaging precursor proteins in lipid bilayers, Science Advances 5, eaav9404 (2019); DOI: 10.1126/sciadv.aav9404

S.Y. Kim, A.E. Pittman, E. Zapata-Mercado, G.M. King, W.C. Wimley, & K. Hristova, Mechanism of Action of Peptides That Cause the pH-Triggered Macromolecular Poration of Lipid Bilayers, Journal of the American Chemical Society 141, 6706 (2019); DOI: 10.1021/jacs.9b01970

M. Utjesanovic*, T.R. Matin*, K.P. Sigdel, G.M. King & I. Kosztin, Multiple stochastic pathways in forced peptide-lipid membrane detachment, Scientific Reports, 9, 451 (2019); *equal contribution; DOI: 10.1038/s41598-018-36528-4

N. Chada, K. Chattrakun, B.P. Marsh, C. Mao, P. Bariya, & G.M. King, Single-molecule observation of nucleotide induced conformational changes in basal SecA-ATP hydrolysis, Science Advances 4, eaat8797, (2018). DOI: 10.1126/sciadv.aat8797

K.P. Sigdel, L.A. Wilt, B.P. Marsh, A.G. Roberts, & G.M. King, The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy , Biochemical Pharmacology 156, 302 (2018). DOI: 10.1016/j.bcp.2018.08.017

A.E. Pittman, B.P. Marsh, & G.M. King, Conformations and dynamic transitions of a melittin derivative that forms macromolecule-sized pores in lipid bilayers , Langmuir 34, 8393 (2018). DOI: 10.1021/acs.langmuir.8b00804

K.P. Sigdel, A.E. Pittman, T.R. Matin, & G.M. King, High-Resolution AFM-Based Force Spectroscopy , Nanoscale Imaging, 49 (2018), In: Lyubchenko Y. (eds), Methods in Molecular Biology, vol 1814. Humana Press, New York, NY. DOI: 10.1007/978-1-4939-8591-3_4

S. Li, S.Y. Kim, A.E. Pittman, G.M. King, W.C. Wimley, & K. Hristova, Potent Macromolecule-Sized Poration of Lipid Bilayers by the Macrolittins, A Synthetically Evolved Family of Pore-Forming Peptides , Journal of the American Chemical Society 140, 6441 (2018); DOI: 10.1021/jacs.8b03026

B.P. Marsh, N. Chada, R.R. Sanganna Gari, K.P. Sigdel, & G.M. King, The Hessian Blob Algorithm: Precise Particle Detection in Atomic Force Microscopy Imagery; Scientific Reports 8, 978 (2018); DOI:10.1038/s41598-018-19379-x

T.R. Matin, K.P. Sigdel, M. Utjesanovic, B.P. Marsh, F. Gallazzi, V.F. Smith, I. Kosztin, & G.M. King, Single-molecule peptide-lipid affinity assay reveals interplay between solution structure and partitioning; Langmuir 33, 4057 (2017); DOI: 10.1021/acs.langmuir.7b00100

K.P. Sigdel and G.M. King, Force Detection for Microscopy Based on Direct Tip Trajectory Observation, United States Patent No.: 9,562,927, (2017).

N. Chada, K.P. Sigdel, R.R. Sanganna Gari, T.R. Matin, L.L. Randall, and G.M. King, Glass is a Viable Substrate for Precision Force Microscopy of Membrane Proteins; Scientific Reports 5; 12550 (2015); DOI: 10.1038/srep12550

Y. Zhao, et. al, Transient Collagen Triple Helix Binding to a Key Metalloproteinase in Invasion and Development; Structure 23, 257 (2015); DOI: 10.1016/j.str.2014.11.021

A. Miskowiec, et. al, On the freezing behavior and diffusion of water in proximity to single-supported zwitterionic and anionic bilayer lipid membranes; Europhysics Letters 107, 28008 (2014); DOI:10.1209/0295-5075/107/28008

Y.G. Fulcher, R.R. Sanganna Gari, N.C. Frey, F. Zhang, R.J. Linhardt, G.M. King, and S.R. Van Doren, Heparinoids Activate a Protease, Secreted by Mucosa and Tumors, via Tethering Supplemented by Allostery; ACS Chemical Biology 9, 957 (2014); DOI: 10.1021/cb400898t

K.P. Sigdel, J.S. Grayer, and G.M. King, Three Dimensional Atomic Force Microscopy: Interaction Force Vector by Direct Observation of Tip Trajectory; Nano Letters 13, 5106 (2013); DOI: 10.1021/nl403423p

C. Mao, C. Cheadle, S.J.S. Hardy, A.A. Lily, Y. Suo, R.R. Sanganna Gari, G.M. King, and L.L. Randall, Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species; Proceedings of the National Academy of Sciences of the United States of America 110, 11815 (2013); DOI: 10.1073/pnas.1303289110

R.R. Sanganna Gari, N.C. Frey, C. Mao, L.L. Randall, and G.M. King, Dynamic Structure of the Translocon SecYEG in Membrane: Direct Single Molecule Observations; Journal of Biological Chemistry 288, 16848 (2013); DOI: 10.1074/jbc.M113.471870

A.B. Churnside, R.M. Sullan, D.M. Nguyen, S.O. Case, M. S. Bull, G.M. King, and T.T. Perkins, Routine and timely sub-picoNewton force stability and precision for biological applications of atomic force microscopy; Nano Letters 12, 3557 (2012); DOI: 10.1021/nl301166w

N.B. Ukah, J. Granstrom, R.R. Sanganna Gari, G.M. King, S. Guha, Low-operating voltage and stable organic field-effect transistors with poly (methyl methacrylate) gate dielectric solution deposited from a high dipole moment solvent; Applied Physics Letters 99, 243302 (2011); DOI: 10.1063/1.3669696