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Single Molecule Biophysics

atomic force microscope TypeB composite

An ultrastable single molecule measurement platform (image credit: Greg Kubler)

Individual biological molecules can be directly interrogated by techniques such as atomic force microscopy (AFM). In contrast, bulk methods yield ensemble averages that can obscure asynchronous activities.

Further, traditional structural characterization techniques are notoriously difficult to apply to membrane proteins. However, these ubiquitous and pharmaceutically significant molecules are well suited to high-resolution AFM investigations.

We are developing and implementing high-precision single molecule techniques to shed light on the structure, structural energetics, and conformational dynamics of biomolecules including membrane proteins.

A central question is: How does the dynamic structure of these molecules influence their function?

 

News

Krishna and Katie's work in collaboration with the Roberts Group at U Georgia has recently been published - congrats! Click here to see the paper.

Work on SecA-E. coli lipid bilayer interactions has just been published - congrats to all co-authors!

Tu's work on translocation acitivty in surface-supported lipid bilayers has been published - congrats! Click here to see the paper.

Anna successfully defends her PhD - major congrats to Dr. Pittman!

Major kudos to Raghu, Tu and co-authors for the new paper on imaging Sec translocases in action that was just published in Science Advances. Click here for a news story about the work "A microscopic topographic map of cellular function".

Congrats to Anna and co-authors for the new publication on pore-forming peptides in JACS!

[More News]

 

Contact Information

  • Prof. Gavin M. King
  • Department of Physics
  • Joint with Biochemistry
  • University of Missouri
  • 223 Physics Building UMC
  • Columbia MO 65211-7010
  • office: (573) 882-3217
  • lab: (573) 884-6795
  • kinggm@missouri.edu

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